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Laboratory for the study of xenobiotics in biological systems (Laboratory)
Medical Faculty in Novi Sad

• Research on drug metabolism in vivo and in vitro conditions 
• Development of analytical methods for pharmacokinetic studies
• The effect on the pharmacokinetics of the pharmaceutical formulations of drugs
• New antidiabetic drugs
• New bile acid derivatives
• Genetic and epigenetic studies on nanotoxicology 

• Passage of drugs through biological membranes,

Name email Host institution
true Mikov Momir momir.mikov@otago.ac.nz Medical Faculty in Novi Sad

The results of investigation by our team showed that bile acids alone exerts a significant hypoglycemic effect and thus may potentiate the effect of other hypoglycemic agents. Hypoglycemic effect in diabetic animals is determined and after the application of this effect is achieved by probiotikakoji insulin-independent mehanizmima.Najizraženiji hypoglycemic effect in diabetic animals was observed in the combined use of a bile acid with gliclazide and probiotics suggesting significant interaction between the two substances whose mechanisms at the molecular level remains to be to examine. It was also found that a semi-synthetic derivative of a bile acid, 12-monoketocholic acid (MKC) has the potential to modify the biophysical properties of the cell membranes and to influence the function and activity of transport proteins of membrane-bound, changing the transport of drugs through biological membranes, such as may result in altered pharmacokinetic characteristics of the drug. Thus, it was shown that MCC enhances the delivery of drugs on the central nervous system, increases the absorption of tramadol and its transport to the brain and thereby affected to povećanjenjegovog analgesic effects. Similarly, it was shown that deoxycholic acid leads to an increased transmission glikazida to the CNS. The most probable mechanism is a modification of the passage and connection in otvaranjetesnih KMB or incorporation of deoxycholic acid in the cell membrane allowing the transfer jeolakšan gliclazide. In addition, the team's results showed a significant change of pharmacokinetic parameters and MKC gliclazide after oral administration after probiotic treatment, pointing to the importance of the intestinal flora and the probiotic in the alteration of the pharmacokinetic and pharmacodynamic properties of the pharmacologically active ingredient.

Project title Project type
Serbian Ministry of Sciences Grant, integrative and interdisciplinary investigation project, ”Interaction of xenobiotics and their effects in biomedical systems” 2011-2014. (Principal investigator Prof. Dr. Momir Mikov) National
“The influence of 3α,7α-dihydroxy-12-oxo-5β cholanate on gliclazide and glucose intestinal permeation in diabetic rats” - University of Otago Grant 2004-2007. (Principal investigator Prof. Dr. Momir Mikov) Uluslararası
Molecular markers in strategy of sustainable development of health care for patients with malignant hematological diseases in APV”, Provincial Secretariat for Science and Technological Development of the Government of Autonomous Province of Vojvodina, 114-451-2198/2012-02, 2012-2013. (Principal investigator Prof. Dr. Karmen Stankov) National
Bilateral project of cooperation between the Ministry of Science, Republic of Serbia and CNRS, France, grant No. 451-03- 2405/2007-02/12-1 “Is KIT a dependence receptor and as such a new guardian of haematological tumorigenesis” 2007-2009. (Principal investigator Prof. Dr. Karmen Stankov) Uluslararası
Cost-effective microfluidic electronic devices for optimal drug administration based on fractional pharmacokinetics for leukemia treatments (MEDLEM) Uluslararası
Optimization of the methotrexate pharmacokinetics to individualize the treatment of leukemia using a fractional and microfluidic electronic device National
Development and application of advanced chromatographic and spectrometric methods for analysis of xenobiotics and pathways for their degradation in biotic and abiotic samples National
Modulators of alpha cell transdifferentiation and plasticity of pancreatic epithelium in experimentally induced diabetes mellitus National
Renewal of industrial cannabis in the light of current agronomic-medical challenges National
Examination of pharmacodynamic and toxicological effects of medicinal herbs grown in the area of ​​Vojvodina National
Resource Name Type
Software LekAs Special software
Works published in magazines with SCI list in 2017:

1. Mikov M, Ðanić (Stojančević) M, Pavlović N, Stanimirov B, Goločorbin-Kon S, Stankov K, Al-Salami H. The Role of Drug Metabolites in the Inhibition of Cytochrome P450 Enzymes. Eur J Drug Metab Pharmacokinet. 2017: DOI 10.1007/s13318-017-0417-y

2. Ilić V, Vukmirović S, Stilinović N, Čapo I, Arsenović M, Milijašević B. Insight into anti-diabetic effect of low dose of stevioside. Biomedicine & Pharmacotherapy 2017;90:216-21.

3. Vukmirovic S, Kusturica M, Milijasevic B, Trifunovic J, Tomas A, Mikov M. Fermentation Potentiates Antimotility Properties of Chamomile Ligulate Flower Extracts. Indian Journal of Pharmaceutical Sciences 2017;78(5):691-4.

4. Zaimović-Šahman M, Vukmirović S, Tomić N, Stilinović N, Horvat O, Tomić Z. Relationship between outpatient antibiotic use and the prevalence of bacterial infections in Montenegro. Vojnosanitetski pregled 2017;74(1):46-50.

5. Rašković A, Gigov S, Čapo I, Kusturica MP, Milijašević B, Kojić-Damjanov S, Martić N. Antioxidative and Protective Actions of Apigenin in a Paracetamol-Induced Hepatotoxicity Rat Model. European Journal of Drug Metabolism and Pharmacokinetics 2017;2:1-8.

6. Tomas A, Kusturica MP, Tomić Z, Horvat O, Koprivica DD, Bukumirić D, Sabo A. Self-medication with antibiotics in Serbian households: a case for action?. International Journal of Clinical Pharmacy 2017. 8:1-7.

7. Paut Kusturica M, Tomas A, Sabo A. Disposal of Unused Drugs: Knowledge and Behavior Among People Around the World. Rev Environ Contam Toxicol. 2017;240:71-104.

Works published in the magazines with the SCI list of 2016. godine:

1. Đanić (Stojančević) M, Pavlović N, Stanimirov B, Vukmirović S, Nikolić K, Agbaba D, Mikov M. The influence of bile salts on the distribution of simvastatin in octanol/buffer system. Drug Dev Ind Pharm. 2016;42(4):661-7.

2. Đanić (Stojančević) M, Pavlović N, Stanimirov B, Stojančević T, Goločorbin-Kon S, Bojić G, Mikov M. Docking-based preliminary study on the interactions of bile acids with drugs at the transporter level in intestinal bacteria. Eur Rev Med Pharmaco. 2016;20(3):553-60.

3. Samojlik I, Petković S, Stilinović N, Vukmirović S, Mijatović V, Božin B. Pharmacokinetic Herb-Drug Interaction between Essential Oil of Aniseed (Pimpinella anisum L., Apiaceae) and Acetaminophen and Caffeine: A Potential Risk for Clinical Practice. Phytotherapy Research 2016. 30(2):253-9.

4. Paut Kusturica M, Tomas A, Tomic Z, Bukumiric D, Corac A, Horvat O, Sabo A. Analysis of expired medications in Serbian households. Zdr Varst. 2016;55(3):195-201.

5. Tomić Z, Tomas A, Vukmirović S, Mikov M, Horvat O, Tomić N, Sabo A. Do We Bury Antibacterials When Launching? Cefaclor Example. Journal of pharmaceutical sciences. 2016;105(3):1295-300.

6. Tomas A, Tomić Z, Milijašević B, Ban M, Horvat O, Vukmirović S, Sabo A. Patterns of prescription antihypertensive drug utilization in Novi Sad and adherence to treatment guidelines. Vojnosanitet pregled. 2016 73(6): 531–537.

Works published in the magazines with the SCI list of 2015:

1. Mooranian A, Negrulj R, Mathavan S, Martinez J, Sciarretta J, Chen-Tan N, Mukkur TK, Mikov M, Lalic-Popovic M, Đanić (Stojančević) M, Golocorbin-Kon S, Al-Salami H. An advanced microencapsulated system: a platform for optimized oral delivery of antidiabetic drug-bile acid formulations. Pharm Dev Technol. 2015;20(6):702-9.

2. Čapo I, Hinić N, Lalošević D, Vučković N, Stilinović N, Marković J, Sekulić S.Vitamin C Depletion in Prenatal Guinea Pigs as a Model of Lissencephaly Type II. Veterinary Pathology. 2015. 52(6):1263-1271

3. Paut-Kusturica M, Tomić Z, Bukumirić N, Ninković Lj, Tomas A, Stilinović N, Sabo A. Home pharmacies in Serbia: an insight into self-medication practice. International Journal of Clinical Pharmacy 2015. 37(2):373-378

4. Sabo A, Tomas A, Tomić N, Mikov M, Horvat O, Popović R, Tomić Z. Pharmacokinetic/pharmacodynamic based dosing of ciprofloxacin in complicated urinary tract infections. Bangladesh Journal Of Pharmacology. 2015; 10(3): 621-626.

5. Kusturica MP, Tomic Z, Bukumiric Z, Horvat O, Pavlovic N, Mikov M, Sabo A. Antibiotics in Serbian Households: A Source of Potential Health and Environmental Threats?. Central European Journal of Public Health. 2015;23(2):114.

Works published in the magazines with the SCI list of  2014. godine:

1. Đanić (Stojančević) M, Bojić G, Salami HA, Mikov M. The Influence of Intestinal Tract and Probiotics on the Fate of Orally Administered Drugs. Curr Issues Mol Biol. 2014;16(2):55-68.

2. Mooranian A, Negrulj R, Mathavan S, Martinez J, Sciarretta J, Chen-Tan N, Mukkur T, Mikov M, Lalic-Popovic M, Đanić (Stojančević) M, Golocorbin-Kon S, Al-Salami H. Stability and Release Kinetics of an Advanced Gliclazide-Cholic Acid Formulation: The Use of Artificial-Cell Microencapsulation in Slow Release Targeted Oral Delivery of Antidiabetics. J Pharm Innov. 2014;9:150-7.

3. Milijašević B, Stefanović D, Lalić-Popović M, Tomić Z, Kolarović J, Lalošević D, Mikov M. Acute toxic effects of single dose dacarbazine: hematological and histological changes in an animal model. Biotech Histochem. 2014 Nov;89(8):583-90. doi: 10.3109/10520295.2014.918653.

4. Vasović V, Rasković A, Mikov M, Mikov I, Milijasević B, Vukmirović S, Budakov Z. Effect of aqueous solution of stevioside on pharmacological properties of some cardioactive drugs.Vojnosanit Pregl. 2014 Jul;71(7):667-72.

5.Vasović V, Vukmirović S, Mikov M, Mikov I, Budakov Z, Stilinović N, Milijasević B. Influence of bile acid derivates on morphine analgesic effect in mice. Vojnosanit Pregl. 2014 Aug;71(8):767-71.

6. Mijatović V, Samojlik I, Ajduković N, Đurendić-Brenesel M, Petković S. Methadone-related deaths – epidemiological, pathohistological, and toxicological traits in 10-year retrospective study in Vojvodina, Serbia. J Forensic Sci. 2014 Sep;59(5):1280-5. doi: 10.1111/1556-4029.12425.

7. Stilinović N, Skrbić B, Zivančev J, Mrmoš N, Pavlović N, Vukmirović S. The level of elements and antioxidant activity of commercial dietary supplement formulations based on edible mushrooms. Food Funct. 2014 Oct 8. doi: 10.1039/c4fo00703d .

Works published in the magazines with the SCI list of 2013. godine:

1. Lalić-Popović M, Vasović V, Milijašević B, Goločorbin-Kon S, Al-Salami H, Mikov M. Deoxycholic Acid as a Modifier of the Permeation of Gliclazide through the Blood Brain Barrier of a Rat. J Diabetes Res. 2013;2013:598603. doi: 10.1155/2013/598603.

2. Stepanov V, Stankov K, Mikov M. The bile acid membrane receptor TGR5: a novel pharmacological target in metabolic, inflammatory and neoplastic disorders. J Recept Signal Transduct Res. 2013 Aug;33(4):213-23. doi: 10.3109/10799893.2013.802805.

3. Odalovic M, Vezmar Kovacevic S, Nordeng H, Ilic K, Sabo A, Tasic L. Predictors of the use of medications before and during pregnancy. Int J Clin Pharm. 2013 Jun;35(3):408-16. doi: 10.1007/s11096-013-9750-7.

4. Sabo A, Horvat O, Stilinovic N, Berenji J, Vukmirovic S. Industrial hemp decreases intestinal motility stronger than indian hemp in mice. Eur Rev Med Pharmacol Sci. 2013 Feb;17(4):486-90.

5. Lalic-Popovic M, Paunkovic J, Grujic Z, Golocorbin-Kon S, Al-Salami H, Mikov M. Diabetes and hypertension increase the placental and transcellular permeation of the lipophilic drug diazepam in pregnant women. BMC Pregnancy Childbirth. 2013 Oct 17;13(1):188.

6. Mihajlović J, Pechlivanoglou P, Sabo A, Tomić Z, Postma MJ. Cost-effectiveness of everolimus for second-line treatment of metastatic renal cell carcinoma in Serbia. Clin Ther. 2013 Dec;35(12):1909-22. doi: 10.1016/j.clinthera.2013.10.004.

7. Đanić (Stojančević) M, Pavlović N, Goločorbin-Kon S, Mikov M. Application of bile acids in drug formulation and delivery. Frontiers in Life Science (HFSP Journal) 2013;7(3-4):112-122 DOI:10.1080/21553769.2013.879925

8. Samojlik I, Mijatović V, Gavarić N, Krstin S, Božin B. Consumers’ attitude towards the use and safety of herbal medicines and herbal dietary supplements in Serbia. Int J Clin Pharm. 2013 Oct;35(5):835-40. doi: 10.1007/s11096-013-9819-3.

9. Andrejić BM, Mijatović VM, Samojlik IN, Horvat OJ, Ćalasan JD, Đolai MA. The influence of chronic intake of saccharin on rat hepatic and pancreatic function and morphology: gender differences. Bosn J Basic Med Sci. 2013 May;13(2):94-9.

10. Mijatović V, Dickov A, Petković S, Popov T, Samojlik I. Safety assessment of low doses of methadone in combination with benzodiazepines in real occasions during methadone maintenance treatment. Heroin Addict Relat Clin Probl 2013;15(3): 29-34. .

Works published in the magazines with the SCI list of 2012. godine:

1. Stanimirov B, Stankov K, Mikov M. Pleiotropic functions of bile acids mediated by the farnesoid X receptor. Acta Gastroenterol Belg. 2012 Dec;75(4):389-98.

2. Velickovic-Radovanovic R, Mikov M, Catic-Djordjevic A, Stefanovic N, Stojanovic M, Jokanovic M, Cvetkovic T. Tacrolimus as a part of immunosuppressive treatment in kidney transplantation patients: sex differences.Gend Med. 2012 Dec;9(6):471-80. doi: 10.1016/j.genm.2012.10.003.

3. Pavlović N, Stankov K, Mikov M. Probiotics–interactions with bile acids and impact on cholesterol metabolism.Appl Biochem Biotechnol. 2012 Dec;168(7):1880-95. doi: 10.1007/s12010-012-9904-4.

4. Đanić (Stojančević) M, Stankov K, Mikov M. The impact of farnesoid X receptor activation on intestinal permeability in inflammatory bowel disease.Can J Gastroenterol. 2012 Sep;26(9):631-7.

5. Stankov K, Draskovic D, Mikov M. Ethical and legal aspects of oncogenomics. J BUON. 2012 Apr-Jun;17(2):383-8.

6. Mikov I, Stankov K, Vasovic V, Mikov A, Golocorbin-Kon S, Mikov M. Effect of simultaneous exposure to benzene and ethanol on urinary thioether excretion. Int J Occup Saf Ergon. 2012;18(1):107-11

7. Sabo A, Horvat O, Stilinovic N, Berenji J, Vukmirovic S. Industrial hemp decreases intestinal motility stronger than indian hemp in mice. Eur Rev Med Pharmacol Sci. 2013 Feb;17(4):486-90.

8. Kusturica MP, Sabo A, Tomic Z, Horvat O, Solak Z. Storage and disposal of unused medications: knowledge, behavior, and attitudes among Serbian people. Int J Clin Pharm. 2012 Aug;34(4):604-10. doi: 10.1007/s11096-012-9652-0.

9. Pavlović N, Stanimirov B, Stojančević M, Paut-Kusturica M, Stoimenova A, Goločorbin-Kon S, Mikov M. An insight on differences in availability and reimbursement of orphan medicines among Serbia, Bulgaria and Sweden.Biotechnol & Biotechnol Eq. 2012; 26(5):3236-41.

10. Odalovic M, Vezmar Kovacevic S, Ilic K, Sabo A, Tasic L. Drug use before and during pregnancy in Serbia. Int J Clin Pharm. 2012 Oct;34(5):719-27. doi: 10.1007/s11096-012-9665-8. 

11. Horvat O, Mijatović V, Čalasan J, Sabo A. Outpatient utilization of non-steroidal anti-inflammatory drugs in three largest municipalities in South Backa district. Srp Arh Celok Lek. 2012 May-Jun;140(5-6):339-43. Serbian.

12. Al-Salami H, Butt G, Tucker I, Golocorbin-Kon S, Mikov M. Probiotics decreased the bioavailability of the bile acid analog, monoketocholic acid, when coadministered with gliclazide, in healthy but not diabetic rats. Eur J Drug Metab Pharmacokinet. 2012 Jun;37(2):99-108. doi: 10.1007/s13318-011-0060-y.

13. Vapa I, Torres VM, Djordjevic A, Vasovic V, Srdjenovic B, Simic VD, Popović JK. Effect of fullerenol C(60)(OH) (24) on lipid peroxidation of kidneys, testes and lungs in rats treated with doxorubicine. Eur J Drug Metab Pharmacokinet. 2012 Dec;37(4):301-7. doi: 10.1007/s13318-012-0092-y.

14. Erić M, Leppée M, Sabo A, Culig J. Beta-lactam antibiotics during pregnancy: a cross-sectional comparative study Zagreb-Novi Sad. Eur Rev Med Pharmacol Sci. 2012 Jan;16(1):103-10. 15. Samojlik I, Mijatović V, Petković S, Skrbić B, Božin B. The influence of essential oil of aniseed (Pimpinella anisum, L.) on drug effects on the central nervous system. Fitoterapia. 2012 Dec;83(8):1466-73. doi: 10.1016/j.fitote.2012.08.012. .

Radovi publikovani u časopisima sa SCI liste u toku 2011. godine:

1. Sabo A, Tomić Z, Stilinović N, Milijašević B, Mikov M, Vukmirović S, Horvat O. Consumption of serum lipid-reducing drugs in Serbia compared with Scandinavian countries: a population-based study, 2004-2008. Pharmacoepidemiol Drug Saf. 2011 Jan;20(1):45-9. doi: 10.1002/pds.2045.

2. Perisić Z, Perisić N, Golocorbin Kon S, Vesović D, Jovanović AM, Mikov M. The influence of probiotics on the cervical malignancy diagnostics quality.Vojnosanit Pregl. 2011 Nov;68(11):956-60.

3. Cekić V, Vasović V, Jakovljević V, Lalošević D, Čapo I, Mikov M, Sabo A. Effect of chromium enriched fermentation product of barley and brewer’s yeast and its combination with rosiglitazone on experimentally induced hyperglycaemia in mice. Srp Arh Celok Lek. 2011 Sep-Oct;139(9-10):610-8. Serbian.

4. Rašković A, Stilinović N, Kolarović J, Vasović V, Vukmirović S, Mikov M. The protective effects of silymarin against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats. Molecules. 2011 Oct 12;16(10):8601-13. doi: 10.3390/molecules16108601.

5. Al-Salami H, Butt G, Tucker I, Golocorbin-Kon S, Mikov M. Probiotics decreased the bioavailability of the bile acid analog, monoketocholic acid, when coadministered with gliclazide, in healthy but not diabetic rats.Eur J Drug Metab Pharmacokinet. 2012 Jun;37(2):99-108. doi: 10.1007/s13318-011-0060-y.

6. Golocorbin Kon S, Mikov M. Counterfeit drugs as a gobal threat to health.Med Pregl. 2011 May-Jun;64(5-6):285-90.

7. Velicković-Radovanović R, Mikov M, Paunović G, Djordjević V, Stojanović M, Cvetković T, Djordjević AC. Gender differences in pharmacokinetics of tacrolimus and their clinical significance in kidney transplant recipients. Gend Med. 2011 Feb;8(1):23-31. doi: 10.1016/j.genm.2011.01.003.

8. Calasan J, Mijatović V, Horvat O, Varga J, Sabo A, Stilinović N. The outpatient utilization of non-steroidal anti-inflammatory drugs in South Bačka District, Serbia.Int J Clin Pharm. 2011 Apr;33(2):246-51. doi: 10.1007/s11096-011-9487-0.

9. Lalic M, Pilipovic A, Golocorbin-Kon S, Gebauer-Bukurov K, Bozic K, Mikov M, Cvejic J. Comparison of dissolution profiles and serum concentrations of two lamotrigine tablet formulations.Drugs R D. 2011;11(1):53-60. doi: 10.2165/11588260-000000000-00000.

10. Cekic V, Vasovic V, Jakovljevic V, Mikov M, Sabo A. Hypoglycaemic action of stevioside and а barley and brewer’s yeast based preparation in the experimental model on mice. Bosn J Basic Med Sci. 2011 Feb;11(1):11-6.

11. Duborija-Kovacevic N, Jakovljevic V, Sabo A, Tomic Z, Pajovic B, Perovic D. Tolerability and toxicity of lipidosterolic extract of American dwarf palm Serenoa repens in Wistar rats: well-known extract, new insight. Eur Rev Med Pharmacol Sci. 2011 Nov;15(11):1311-7.

12. Mijatović V, Calasan J, Horvat O, Sabo A, Tomić Z, Radulović V. Consumption of non-steroidal anti-inflammatory drugs in Serbia: a comparison with Croatia and Denmark during 2005-2008. Eur J Clin Pharmacol. 2011 Feb;67(2):203-7. doi: 10.1007/s00228-010-0951-x. .

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